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dc.contributor.authorBasha, Muzaitul Akma Mustapa Kamal
dc.contributor.authorMajid, Hazreen Abdul
dc.contributor.authorRazali, Nuguelis
dc.contributor.authorRashed, Aswir Abd
dc.contributor.authorMuhammad, Hussin
dc.contributor.authorYahya, Abqariyah
dc.date.accessioned2024-02-02T11:43:44Z
dc.date.available2024-02-02T11:43:44Z
dc.date.issued2021-06-29
dc.identifier.citationBasha, M. A. M. K., Majid, H. A., Razali, N., Rashed, A. A., Muhammad, H., & Yahya, A. (2021). Longitudinal vitamin D deficiency among Malaysian pregnant women and its correlation with neonatal serum 25-hydroxyvitamin D levels. Frontiers in public health, 9, 654292. https://doi.org/10.3389/fpubh.2021.654292en
dc.identifier.issn2296-2565
dc.identifier.urihttps://aecc.archive.knowledgearc.net/handle/123456789/260
dc.descriptionAvailable under License - Creative Commons Attribution: https://creativecommons.org/licenses/by/4.0/en
dc.description.abstractObjective: This study aimed to investigate the longitudinal relationship between maternal vitamin D concentrations during pregnancy and neonatal vitamin D concentrations at birth. Materials and Methods: A prospective cohort of 236 healthy pregnant women from various ethnicity in early pregnancy (≤20 weeks of pregnancy) was followed at late pregnancy (28–40 weeks of pregnancy) and birth. Maternal serum 25-hydroxyvitamin D (25(OH)D) was assessed at early pregnancy (baseline) and late pregnancy, while neonatal cord serum 25(OH)D at birth. General estimating equations (GEE) were used to analyze the longitudinal association of maternal serum 25(OH)D levels during pregnancy and neonatal cord serum 25(OH)D levels at birth with adjusting for the time exposure, maternal weight gain, ethnicity, and skin type. Results: The results showed that the prevalence of vitamin D deficiency (25(OH)D <50 nmol/L) was at 89.9, 92.2, and 96.1% in early, late pregnancy and in neonatal cord serum, respectively. The GEE analysis showed a trend that longitudinal vitamin D deficiency during pregnancy leads to lower vitamin D concentrations in neonatal cord blood (RR = 1.17; 95% CI (1.05–1.36); p = 0.04). Conclusion: Longitudinal vitamin D deficiency during pregnancy leads to vitamin D deficiency in neonates at birth. A further trial is needed to affirm this association.en
dc.language.isoenen
dc.publisherFrontiers in Public Healthen
dc.subjectVitamin D deficiencyen
dc.subjectCord blooden
dc.subjectPregnancyen
dc.subjectNeonatesen
dc.subject25(OH)Den
dc.titleLongitudinal vitamin D deficiency among Malaysian pregnant women and its correlation with neonatal serum 25-hydroxyvitamin D levelsen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.3389/fpubh.2021.654292


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