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dc.contributor.authorKhoo, Xin-Hui
dc.contributor.authorChong, Chun-Wie
dc.contributor.authorTalha, Abdul Malik
dc.contributor.authorPhilip, Koshy
dc.contributor.authorTeh, Cindy Shuan-Ju
dc.contributor.authorIsa, Adib Mat
dc.contributor.authorWong, Mung Seong
dc.contributor.authorChew, Deborah Chia-Hsin
dc.contributor.authorWong, Zhiqin
dc.contributor.authorJusoh, Nor Syarahani
dc.contributor.authorMaksum, Noorhuda Madihah Mohamed
dc.contributor.authorMokhtar, Norfilza Mohd
dc.contributor.authorMajid, Hazreen Abdul
dc.contributor.authorAli, Raja Affendi Raja
dc.contributor.authorLee, Yeong-Yeh
dc.contributor.authorMahadeva, Sanjiv
dc.date.accessioned2023-05-25T09:55:41Z
dc.date.available2023-05-25T09:55:41Z
dc.date.issued2023-03-12
dc.identifier.citationKhoo, X. H., Chong, C. W., Talha, A. M., Philip, K., Teh, C. S. J., Isa, A. M., Wong, M. S., Chew, D. C., Wong, Z., Jusoh, N. S., Maksum, N. M. M., Mokhtar, N. M., Majid, H. A., Ali, R. A. R., Lee, Y., & Mahadeva, S. (2023). The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi‐centre study. Journal of Gastroenterology and Hepatology. https://doi.org/10.1111/jgh.16174en
dc.identifier.issn1440-1746
dc.identifier.urihttps://aecc.archive.knowledgearc.net/handle/123456789/186
dc.descriptionThis is the peer reviewed version of the following article: Khoo, X. H., Chong, C. W., Talha, A. M., Philip, K., Teh, C. S. J., Isa, A. M., Wong, M. S., Chew, D. C., Wong, Z., Jusoh, N. S., Maksum, N. M. M., Mokhtar, N. M., Majid, H. A., Ali, R. A. R., Lee, Y., & Mahadeva, S. (2023). The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi‐centre study. Journal of Gastroenterology and Hepatology, 38(8), 1259–1268., which has been published in final form at https://doi.org/10.1111/jgh.16174. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.en
dc.description.abstractBackground and Aim The gut microbiota in irritable bowel syndrome (IBS) is known to vary with diet. We aim to (i) analyze the gut microbiota composition of IBS patients from a multi-ethnic population and (ii) explore the impact of a low FODMAP diet on gastrointestinal symptoms and gut microbiota composition among IBS patients. Methods A multi-center study of multi-ethnic Asian patients with IBS was conducted in two phases: (i) an initial cross-sectional gut microbiota composition study of IBS patients and healthy controls, followed by (ii) a single-arm 6-week dietary interventional study of the IBS patients alone, exploring clinical and gut microbiota changes. Results A total of 34 adult IBS patients (IBS sub-types of IBS-D 44.1%, IBS-C 32.4%, and IBS-M 23.5%) and 15 healthy controls were recruited. A greater abundance of Parabacteroides species with lower levels of bacterial fermenters and short-chain fatty acids producers were found among IBS patients compared with healthy controls. Age and ethnicity were found to be associated with gut microbiota composition. Following a low FODMAP dietary intervention, symptom and quality of life improvement were observed in 24 (70.6%) IBS patients. Symptom improvement was associated with adherence to the low FODMAP diet (46.7% poor adherence vs 92.9% good adherence, P = 0.014), and gut microbiota patterns, particularly with a greater abundance of Bifidobacterium longum, Anaerotignum propionicum, and Blautia species post-intervention. Conclusion Gut microbiota variation in multi-ethnic IBS patients may be related to dietary intake and may be helpful to identify patients who are likely to respond to a low FODMAP diet.en
dc.language.isoenen
dc.publisherJournal of Gastroenterology and Hepatology
dc.titleThe impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi‐centre studyen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1111/jgh.16174


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